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Doxorubicin Hydrochloride Liposome (Pegylated) Injections Doxorubicin Hydrochloride Liposome (Pegylated) Injections
Doxorubicin Hydrochloride Liposome (Pegylated) Injections
Doxorubicin Hydrochloride Liposome (Pegylated) Injections

Doxorubicin Hydrochloride Liposome (Pegylated) Injections

20.00 - 25.00 USD ($)/Unit

Product Details:

  • Enzyme Types Other
  • Feature Other
  • Ingredients Other
  • Application Other
  • Ph Level 3-5
  • Temperature Needed For Fermentation 10-25 Celsius (oC)
  • Physical Color/Texture Other
  • Supply Ability : 1000 Unit Per Day
  • Click to view more

Price And Quantity

  • 10 Unit
  • 20.00 - 25.00 USD ($)/Unit

Product Specifications

  • 10-25 Celsius (oC)
  • Other
  • Store at Dry And Cool Place
  • 2-3 Years
  • Other
  • Other
  • Normal Smell
  • Other
  • Other
  • NO
  • 3-5

Trade Information

  • Nhavasheva Port, Hajira Port, Mundra Port.
  • Western Union, Telegraphic Transfer (T/T), Letter of Credit (L/C), Cash in Advance (CID), Cash Advance (CA)
  • 1000 Unit Per Day
  • 5-6 Days
  • Yes
  • If order is confirmed we will reimburse the sample cost
  • Monocarton pack alongwith Leaflet.
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
  • All India

Product Description

pegylated liposomal doxorubicin hydrochloride is a A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Detailed information such as uses, side-effects, reviews, questions, interactions, and precautions is given here.

Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids. Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects; a liposomal formulation of doxorubicin also modulates toxicity, specifically the cardiac effects commonly seen with anthracycline antitumor drugs.

Pegylated liposomal doxorubicin is one of a new class of drug formulations that is delivered in vesicles called liposomes. The doxorubicin molecules in pegylated liposomal doxorubicin are encapsulated in a bilayer sphere of lipids. This vesicle is then surrounded by a dense layer of polyethylene glycol (PEG), hence the name pegylated liposomal doxorubicin. The size of the liposomes, approximately 100 nm, prevents them from entering tissues with tight capillary junctions, such as the heart and gastrointestinal tract, as well as selectively depositing the liposome into the tumor. In contrast to normal vessels, the vessels of the tumor are tortuous, dilated, have morphologically abnormal endothelial cells, and are leaky due to large spaces between pericytes.

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